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|Title:||Trends in colon and rectal cancer incidence in Australia from 1982 to 2014: Analysis of data on over 375,000 cases|
|Authors:||Feletto E; Yu XQ; Lew J-B; St John DJB; Jenkins MA; Macrae FA; Mahady SE; Canfell K|
|Categories:||Cancer Type - Bowel Colorectal Cancer|
|Journal Title:||Cancer, Epidemiology, Biomarkers and Prevention|
|Abstract:||Background: Incidence of pancreatic cancer is higher in African Americans than in U.S. whites. We hypothesized that poor oral health, disproportionately common in African Americans and associated with increased risk of pancreatic cancer in several studies of predominantly white populations, may play a role in this disparity. Methods: We examined the relation of self-reported measures of oral health (periodontal disease and adult tooth loss) in relation to pancreatic cancer incidence in the prospective Black Women's Health Study (BWHS). Cox proportional hazard analyses were used to calculate HRs of pancreatic cancer for women with periodontal disease, tooth loss, or both, relative to women who reported neither. Multivariable models adjusted for age, cigarette smoking, body mass index (BMI), type 2 diabetes, and alcohol consumption. Results: Participants aged 33 to 81 were followed for an average of 9.85 years from 2007 through 2016, with occurrence of 78 incidence cases of pancreatic cancer. Multivariable HRs for pancreatic cancer incidence were 1.77 [95% confidence interval (CI) 0.57–5.49] for periodontal disease with no tooth loss, 2.05 (95% CI, 1.08–3.88) for tooth loss without report of periodontal disease, and 1.58 (95% CI, 0.70–3.57) for both tooth loss and periodontal disease. The HR for loss of at least five teeth, regardless of whether periodontal disease was reported, was 2.20 (95% CI, 1.11–4.33). Conclusions: The poor oral health experienced by many African Americans may contribute to their higher incidence of pancreatic cancer. Impact: Future research will assess associations between the oral microbiome and pancreatic cancer risk in this population.|
|Division:||Cancer Research Division|
|Funding Body:||KC was supported by an NHMRC Fellowship. The research was funded by NIH grants NCI U01CA187508 (J.R. Palmer, H. Gerlovin, and D.S. Michaud), NCI R01CA098663 (J.R. Palmer and Y.C. Cozier), and NCI U01CA164974 (J.R. Palmer, Y.C. Cozier, and H. Gerlovin). Pathology data were obtained from state cancer registries (Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, New Jersey, New York, North Carolina, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, and Virginia); these results do not necessarily represent their views.|
|Appears in Collections:||Research Articles|
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