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|Title:||Lung cancer mortality in Australia: Projected outcomes to 2040|
|Authors:||Luo Q; Yu XQ; Wade SL; Caruana M; Pesola F; Canfell K; O'Connell DL|
|Categories:||Cancer Type - Lung Cancer|
|Journal Title:||Lung Cancer|
|Abstract:||Objectives The aim was to develop and validate a statistical model which uses past trends for lung cancer mortality and historical and current data on tobacco consumption to project lung cancer mortality rates into the future for Australia. Methods We used generalized linear models (GLMs) with Poisson distribution including either age, birth cohort or period, and/or various measures of population tobacco exposure (considering cross-sectional smoking prevalence, cigarettes smoked and tar exposure per capita). Sex-specific models were fitted to data for 1956–2015 and age-standardized lung cancer mortality rates were projected forward to 2040. Possible lags of 20–30 years between tobacco exposure and lung cancer mortality were examined. The best model was selected using analysis of deviance. To validate the selected model, we temporarily re-fitted it to data for 1956–1990 and compared the projected rates to 2015 with the observed rates for 1991–2015. Results The best fitting model used information on age, birth cohort and tar exposure per capita; close concordance with the observed data was achieved in the validation. The forward projections for lung cancer mortality using this model indicate that male and female age-standardized rates will decline over the period 2011–2015 to 2036–2040 from 27.2 to 15.1 per 100,000, and 15.8 to 11.8 per 100,000, respectively. However, due to population growth and ageing the number of deaths will increase by 7.9% for males and 57.9% for females; from 41,040 (24,831 males, 16,209 females) in 2011–2015 to 52,403 (26,805 males, 25,598 females) in 2036–2040. Conclusion In the context of the mature tobacco epidemic with past peaks in tobacco consumption for both males and females, lung cancer mortality rates are expected to continually decline over the next 25 years. However, the number of lung cancer deaths will continue to be substantial, and to increase, in Australia’s ageing population.|
|Division:||Cancer Research Division|
|Funding Body:||KC was supported by a NHMRC Fellowship|
|Appears in Collections:||Research Articles|
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