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Title: Factors associated with prostate specific antigen testing in Australians: Analysis of the New South Wales 45 and Up Study
Authors: Nair-Shalliker V; Bang A; Weber MF; Goldsbury DE; Caruana M; Emery J; Banks E; Canfell K; O'Connell DL; Smith DP
Categories: Cancer Type - Prostate Cancer
Early Detection, Diagnosis, and Prognosis - Technology and/or Marker Testing in a Clinical Setting
Year: 2018
Journal Title: Scientific Reports
Volume: 8
Issue: Article Number: 4261
Abstract: Australia has one of the highest incidence rates of prostate cancer (PC) worldwide, due in part to widespread prostate specific antigen (PSA) testing. We aimed to identify factors associated with PSA testing in Australian men without a diagnosis of prostate cancer or prior prostate disease. Participants were men joining the 45 and Up Study in 2006–2009, aged ≥45 years at recruitment. Self-completed questionnaires were linked to cancer registrations, hospitalisations, health services data and deaths. Men with a history of PC, radical prostatectomy or a “monitoring” PSA test for prostate disease were excluded. We identified Medicare reimbursed PSA tests during 2012–2014. Multivariable logistic regression was used to estimate adjusted odds ratios (OR) for the association between having PSA tests and factors of interest. Of the 62,765 eligible men, 51.8% had at least one screening PSA test during 2012–2014. Factors strongly associated with having a PSA test included having 27+ general practitioner consultations (versus 3–9 consultations; OR = 2.00; 95%CI = 1.90–2.11), benign prostatic hyperplasia treatment (versus none; OR = 1.59(95%CI = 1.49–1.70), aged 60–69 years (versus 50–59 years; OR = 1.54; 95%CI = 1.48–1.60). These results emphasise the important role of primary care in decision making about PSA testing.
Division: Cancer Research Division
Funding Body: This work was supported by a Grant from The Prostate Cancer Foundation of Australia (#NCG 4513). D Smith was supported by a grant from Cancer Institute NSW (#15/CDF/1–10).
DOI: 10.1038/s41598-018-22589-y
Appears in Collections:Research Articles

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