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|Title:||Temporal Trends in Airborne Dust Concentrations at a Large Chrysotile Mine and its Asbestos-enrichment Factories in the Russian Federation During 1951-2001|
|Authors:||Schonfeld SJ; Kovalevskiy EV; Feletto E; Bukhtiyarov IV; Kashanskiy SV; Moissonier M; Straif K; McCormack VA; Schuz J; Kromhout H|
|Categories:||Etiology - Exogenous Factors in the Origin and Cause of Cancer|
Cancer Type - All Cancers combined
|Journal Title:||Annals of Work Exposures and Health|
|Page number start:||797|
|Page number end:||808|
|Abstract:||OBJECTIVES: Mining and processing of chrysotile, an established carcinogen, has been undertaken in Asbest, Russian Federation since the late 1800s. Dust concentrations were routinely recorded at the open-pit mine and its asbestos-enrichment factories. We examined the temporal trends in these dust concentrations from 1951 to 2001. METHODS: Analyses included 89290 monthly averaged gravimetric dust concentrations in six factories (1951-2001) and 1457 monthly averaged concentrations in the mine (1964-2001). Annual percent changes (APC) in geometric mean dust concentrations were estimated for each factory and the mine separately from linear mixed models of the logarithmic-transformed monthly averaged concentrations. RESULTS: Dust concentrations declined significantly in the mine [APC: -1.6%; 95% confidence interval (CI): -3.0 to -0.2] and Factories 1-5 but not 6. Overall factory APCs ranged from -30.4% (95% CI: -51.9 to -8.9; Factory 1: 1951-1955) to -0.6% (95% CI: -1.5 to 0.2; Factory 6: 1969-2001). Factory trends varied across decades, with the steepest declines observed before 1960 [APCs: -21.5% (Factory 2) and -17.4% (Factory 3)], more moderate declines in the 1960s and 1970s [APCs from -10% in Factory 2 (1960s) to -0.3% (not statistically significant) in Factory 4 (1970s)], and little change thereafter. Mine dust concentrations increased in the 1960s (APC: +9.7%; 95% CI: 3.6 to 15.9), decreased in the 1990s (APC: -5.8%; 95% CI: -8.1 to -3.5) and were stable in between. CONCLUSIONS: In this analysis of >90000 dust concentrations, factory dust concentrations declined between 1951 and 1979 and then stabilized. In the mine, dust levels increased in the 1960s, declined in the 1990s and were unchanged in the interim.|
|Division:||Cancer Research Division|
|Funding Body:||This study is funded by the Ministry of Health of the Russian Federation in the framework of the Federal target programme ‘National System of Chemical and Biological Safety of the Russian Federation (2009–2014)’ under a general framework of action between the Federal state budgetary scientific institution ‘Scientific Research Institute of Occupational Health’ and the International Agency for Research on Cancer (IARC). EF’s work is being undertaken during the tenure of an IARC-Australia Postdoctoral Fellowship from the International Agency for Research on Cancer, supported by Cancer Council Australia (CCA). This research was supported in part by the National Cancer Institute (NCI) intramural research program, National Institutes of Health|
|Appears in Collections:||Research Articles|
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