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|Title:||A comparison of parallel dust and fibre measurements of airborne chrysotile asbestos in a large mine and processing factories in the Russian Federation|
|Authors:||Feletto E; Schonfeld SJ; Kovalevskiy EV; Bukhtiyarov IV; Kashanskiy SV; Moissonnier M; Straif K; Schüz J; Kromhout H|
|Categories:||Etiology - Exogenous Factors in the Origin and Cause of Cancer|
|Journal Title:||International Journal of Hygiene and Environmental Health|
|Page number start:||857|
|Page number end:||868|
|Abstract:||INTRODUCTION: Historic dust concentrations are available in a large-scale cohort study of workers in a chrysotile mine and processing factories in Asbest, Russian Federation. Parallel dust (gravimetric) and fibre (phase-contrast optical microscopy) concentrations collected in 1995, 2007 and 2013/14 were used to determine if dust to fibre conversion factors can be estimated. MATERIALS/SUBJECTS AND METHODS: Daily medians of multiple parallel dust and fibre concentrations by sampling points were used to derive fibre to dust ratios. Applying linear mixed models, we estimated best linear unbiased predictions for the fibre to dust ratios. RESULTS AND DISCUSSION: A total of 620 daily median fibre to dust ratios were derived. In the factories, modelled ratios varied by unit, increasing along the stages of asbestos enrichment as expected. In the mine, ratios were higher in winter compared to summer. Overall, the ratios showed a strong negative dependency on dust concentration. CONCLUSIONS: Our study shows that dust to fibre conversion is possible by unit but extrapolations are needed. The patterns for exposure by dust and fibre will be similar but estimated fibre levels will show less contrast due to the conversion factor being smaller at higher dust concentrations.|
|Division:||Cancer Research Division|
|Funding Body:||This study is funded by the Ministry of Health of the Russian Federation in the framework of the Federal target program “National System of Chemical and Biological Safety of the Russian Federation (2009–2014)” under a general framework of action between the Federal state budgetary scientific institution “Scientific Research Institute of Occupational Health” and the International Agency for Research on Cancer (IARC). EF’s work is being undertaken during the tenure of an IARC-Australia Postdoctoral Fellowship from the International Agency for Research on Cancer, supported by Cancer Council Australia (CCA). This research was supported in part by the National Cancer Institute (NCI) intramural research program, National Institutes of Health.|
|Appears in Collections:||Research Articles|
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