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|Title:||Relationship between lifestyle and health factors and severe lower urinary tract symptoms (LUTS) in 106,435 middle-aged and older Australian men: population-based study|
|Authors:||Smith DP; Weber MF; Soga K; Tikellis G; Patel MI; Clements MS; Dwyer T; Latz IK; Banks E|
|Categories:||Etiology - Exogenous Factors in the Origin and Cause of Cancer|
|Journal Title:||PLOS One|
|Abstract:||Abstract BACKGROUND: Despite growing interest in prevention of lower urinary tract symptoms (LUTS) through better understanding of modifiable risk factors, large-scale population-based evidence is limited. OBJECTIVE: To describe risk factors associated with severe LUTS in the 45 and Up Study, a large cohort study. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional analysis of questionnaire data from 106,435 men aged ≥ 45 years, living in New South Wales, Australia. OUTCOME MEASURES AND STATISTICAL ANALYSIS: LUTS were measured by a modified version of the International Prostate Symptom Score (m-IPSS). The strength of association between severe LUTS and socio-demographic, lifestyle and health-related factors was estimated, using logistic regression to calculate odds ratios, adjusted for a range of confounding factors. RESULTS: Overall, 18.3% reported moderate, and 3.6% severe, LUTS. Severe LUTS were more common among men reporting previous prostate cancer (7.6%), total prostatectomy (4.9%) or having part of the prostate removed (8.2%). After excluding men with prostate cancer or prostate surgery, the prevalence of moderate-severe LUTS in the cohort (n = 95,089) ranged from 10.6% to 35.4% for ages 45-49 to ≥ 80; the age-related increase was steeper for storage than voiding symptoms. The adjusted odds of severe LUTS decreased with increasing education (tertiary qualification versus no school certificate, odds ratio (OR = 0.78 (0.68-0.89))) and increasing physical activity (high versus low, OR = 0.83 (0.76-0.91)). Odds were elevated among current smokers versus never-smokers (OR = 1.64 (1.43-1.88)), obese versus healthy-weight men (OR = 1.27 (1.14-1.41)) and for comorbid conditions (e.g., heart disease versus no heart disease, OR = 1.36 (1.24-1.49)), and particularly for severe versus no physical functional limitation (OR = 5.17 (4.51-5.93)). CONCLUSIONS: LUTS was associated with a number of factors, including modifiable risk factors, suggesting potential targets for prevention.|
|Division:||Cancer Research Division|
|Funding Body:||DPS (APP1016598) and EB (APP1042717) are supported by the National Health and Medical Research Council of Australia. This project was supported in part by a JM O’Hara Grant from the Pharmaceutical Society of Western Australia, and by a National Health and Medical Research Council of Australia project grant (APP1024450). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.|
|Appears in Collections:||Research Articles|
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