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|Title:||Time since first sexual intercourse and the risk of cervical cancer|
|Authors:||Canfell K; Sitas F|
|Categories:||Etiology - Exogenous Factors in the Origin and Cause of Cancer|
Cancer Type - Cervical Cancer
|Journal Title:||International Journal of Cancer|
|Page number start:||2638|
|Page number end:||2644|
|Abstract:||Abstract Young age at first sexual intercourse is an important risk factor for cervical cancer, but no simple statistical model of its influence has been established. We investigated the relationship between risk of cervical carcinoma and time since first intercourse using data on monogamous women (5,074 cases and 16,137 controls) from the International Collaboration of Epidemiological Studies of Cervical Cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from pooled data on 20 studies using conditional logistic regression. The OR for invasive cervical carcinoma is approximately proportional to the square of time since first intercourse (exponent 1.95, 95% CI: 1.76–2.15) up to age 45. First cervical infection with human papillomavirus (HPV) often occurs soon after first sexual intercourse, so early age at first sexual intercourse is a reasonable proxy for early age at first exposure to HPV. In addition, age-specific incidence rates of cervical cancer in unscreened populations remain fairly constant above age 45. Cervical cancer thus resembles other cancers caused by strong early-stage carcinogens, with incidence rates proportional to a power of time since first exposure and also resembles cancers of the breast and other hormone-dependent epithelia where a similar flattening of age-specific incidence rates is seen at the time menopausal changes start. Taken together, these observations suggest that HPV vaccination may prevent the majority of cervical cancers by delaying HPV infection without necessarily providing lifetime protection against HPV.|
|Description:||Authors Martyn Plummer,1,* Julian Peto,2 and Silvia Franceschi1, on behalf of the International Collaboration of Epidemiological Studies of Cervical Cancer|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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