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Title: Resilience of a FIT screening programme against screening fatigue: a modelling study
Authors: Greuter MJ; Berkhof J; Canfell K; Lew JB; Dekker E; Coupé VM
Categories: Cancer Type - Bowel & Colorectal Cancer
Early Detection, Diagnosis, and Prognosis - Technology and/or Marker Testing in a Clinical Setting
Year: 2016
Journal Title: BMC Public Health
Volume: 16
Issue: 1
Citation: Greuter MJ, Berkhof J, Canfell K, Lew JB, Dekker E, Coupé VM. Resilience of a FIT screening programme against screening fatigue: a modelling study. BMC Public Health 2016;16(1):1009
Abstract: BACKGROUND: Repeated participation is important in faecal immunochemical testing (FIT) screening for colorectal cancer (CRC). However, a large number of screening invitations over time may lead to screening fatigue and consequently, decreased participation rates. We evaluated the impact of screening fatigue on overall screening programme effectiveness. METHODS: Using the ASCCA model, we simulated the Dutch CRC screening programme consisting of biennial FIT screening in individuals aged 55-75. We studied the resilience of the programme against heterogeneity in screening attendance and decrease in participation rate due to screening fatigue. Outcomes were reductions in CRC incidence and mortality compared to no screening. RESULTS: Assuming a homogenous 63 % participation, i.e., each round each individual was equally likely to attend screening, 30 years of screening reduced CRC incidence and mortality by 39 and 53 %, respectively, compared to no screening. When assuming clustered participation, i.e., three subgroups of individuals with a high (95 %), moderate (65 %) and low (5 %) participation rate, screening was less effective; reductions were 33 % for CRC incidence and 43 % for CRC mortality. Screening fatigue considerably reduced screening effectiveness; if individuals refrained from screening after three negative screens, model-predicted incidence reductions decreased to 25 and 18 % under homogenous and clustered participation, respectively. Figures were 34 and 25 % for mortality reduction. CONCLUSIONS: Screening will substantially decrease CRC incidence and mortality. However, screening effectiveness can be seriously compromised if screening fatigue occurs. This warrants careful monitoring of individual screening behaviour and consideration of targeted invitation systems in individuals who have (repeatedly) missed screening rounds.
Division: Cancer Research Division
Funding Body: KC receives salary support from the Australian National Health and Medical Research Council (CDF 1082989). JBL received the Australia Postgraduate Award PhD Scholarship and Translational Cancer Research Network Top-up scholarship, supported by Cancer Institute NSW.
DOI: 10.1186/s12889-016-3667-8
Appears in Collections:Research Articles

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