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Title: Lifestyle and reproductive risk factors associated with anal cancer in women aged over 50 years
Authors: Coffey K; Beral V; Green J; Reeves G; Barnes I; for the Million Women Study Collaborators (incl. Canfell K)
Categories: Cancer Type - Endometrial Cancer
Cancer Type - Anal Cancer
Etiology - Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors
Year: 2015
Journal Title: British Journal of Cancer
Volume: 112
Issue: 9
Page number start: 1568
Page number end: 1574
Abstract: Abstract BACKGROUND: Anal cancer incidence increases with age and is higher in women than men. Risk factors in this group other than high-risk human papillomavirus infection are unclear. METHODS: In all, 1.3 million women were recruited in 1996-2001 and followed for incident anal cancer. Cox regression models were used to calculate relative risks (RRs) for anal cancer by various potential risk factors. RESULTS: Five hundred and seventeen incident anal cancers were registered over 13 years of follow-up. The largest RR was associated with a history of cervical intraepithelial neoplasia grade 3 (CIN 3; RR=4.03, 95% CI 2.59-6.28). Other factors associated with significantly increased risks in multivariate analyses were: ever smoking (RR=1.49, 1.24-1.80); previous use of oral contraceptives (RR=1.51, 1.24-1.83); nulliparity (RR=1.61, 1.24-2.07); tubal ligation (RR=1.39, 1.13-1.70) and not living with a partner (RR=1.82, 1.40-2.38). The association with smoking was significantly greater for squamous cell carcinoma than adenocarcinoma of the anus (RR 1.66 vs 0.89, P for heterogeneity=0.04). CONCLUSIONS: History of CIN 3, smoking, past oral contraceptive use, nulliparity, tubal ligation and not living with a partner are risk factors for anal cancer in women. There was a significant increase in risk associated with smoking for squamous cell anal cancers but not adenocarcinomas
Division: Cancer Research Division
Funding Body: The Million Women Study is funded by Cancer Research UK (grant no. C570/A16491) and the UK Medical Research Council (grant no. MR/K02700X/1). KC is supported by Cancer Research UK (CR-UK) grant number C38302/A12981, through an Oxford Cancer Research Centre Prize DPhil Studentship.
DOI: 10.1038/bjc.2015.89
Appears in Collections:Research Articles

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