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|Title:||Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial|
|Authors:||Chambers SK; Occhipinti S; Foley E; Clutton S; Legg M; Berry M; Stockler MR; Frydenberg M; Gardiner RA; Lepore SJ; Davis ID; Smith DP|
|Categories:||Cancer Type - Prostate Cancer|
Treatment - Complementary and Alternative Treatment Approaches
|Journal Title:||Journal of Clinical Oncology|
|Page number start:||291|
|Page number end:||297|
|Abstract:||Abstract Purpose Advanced prostate cancer (PC) is associated with substantial psychosocial morbidity. We sought to determine whether mindfulness-based cognitive therapy (MBCT) reduces distress in men with advanced PC. Methods Men with advanced PC (proven metastatic and/or castration-resistant biochemical progression) were randomly assigned to an 8-week, group-based MBCT intervention delivered by telephone (n = 94) or to minimally enhanced usual care (n = 95). Primary intervention outcomes were psychological distress, cancer-specific distress, and prostate-specific antigen anxiety. Mindfulness skills were assessed as potential mediators of effect. Participants were assessed at baseline and were followed up at 3, 6, and 9 months. Main statistical analyses were conducted on the basis of intention to treat. Results Fourteen MBCT groups were conducted in the intervention arm. Facilitator adherence ratings were high (> 93%). Using random-effects mixed-regression models, intention-to-treat analyses indicated no significant changes in intervention outcomes or in engagement with mindfulness for men in MBCT compared with those receiving minimally enhanced usual care. Per-protocol analyses also found no differences between arms in outcomes or engagement, with the exception of the mindfulness skill of observing, which increased over time for men in MBCT compared with usual care (P = .032). Conclusion MBCT in this format was not more effective than minimally enhanced usual care in reducing distress in men with advanced PC. Future intervention research for these men should consider approaches that map more closely to masculinity.|
|Division:||Cancer Research Division|
|Funding Body:||Supported by an Australian National Health and Medical Research grant (APP1024989). S.K.C. is an Australian Research Council Future Fellow. I.D.D. is a National Health and Medical Research Council Practitioner Fellow. DPS is a CINSW Career Development Fellow.|
|Appears in Collections:||Research Articles|
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