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Title: Past cervical intraepithelial neoplasia grade 3, obesity, and earlier menopause are associated with an increased risk of vulval cancer in postmenopausal women
Authors: Coffey K; Gaitskell K; Beral V; Canfell K; Green J; Reeves G; Barnes I
Categories: Cancer Type - Vulvar & Vulval cancer
Etiology - Exogenous Factors in the Origin and Cause of Cancer
Year: 2016
Journal Title: British Journal of Cancer
Volume: 115
Page number start: 599
Page number end: 606
Abstract: Background: Vulval cancer predominantly affects postmenopausal women. A smaller proportion of vulval cancers, particularly at older ages, are now thought to be associated with human papillomavirus infection than previously reported, but other risk factors have not been well examined in prospective cohort studies. Methods: A total of 1.3 million women aged 49–65 years were followed for incident vulval cancer (ICD-10 C51). Adjusted Cox regression models were used to examine the relationship between reproductive and lifestyle factors and risk of vulval cancer. Results: There were 898 vulval cancers registered in the cohort over an average of 14 years of follow-up; 70% were squamous cell carcinomas. Past registration of cervical carcinoma in situ (RR 2.68; 95% CI 1.71–4.18; Po0.001), obesity (RR 1.71; 95% CI 1.44–2.04; Po0.0001), and menopause before the age of 50 years (RR 1.52; 95% CI 1.22–1.89; Po0.001) were associated with a significantly increased risk of subsequent vulval cancer. Conclusion: Past cervical pre-cancer, obesity, and earlier age at menopause are associated with an increased risk of vulval cancer at older ages.
Description: on behalf of the Million Women Study Collaborators
Division: Cancer Research Division
Funding Body: We thank the women and screening centre staff who participated in the Million Women Study. The Million Women Study is funded by Cancer Research UK (Grant No. C570/A16491) and the UK Medical Research Council (Grant No. MR/K02700X/1). K Coffey is supported by Cancer Research UK Grant Number C38302/A12981 through an Oxford Cancer Research Centre Prize DPhil Studentship. K Gaitskell is supported by Cancer Research UK (CRUK) Grant Number C38302/A17318 through a CRUK Oxford Centre Clinical Research Training Fellowship. K Canfell receives salary support from the National Health and Medical Research Council Australia (CDF # 1082989).
DOI: 10.1038/bjc.2016.165
Appears in Collections:Research Articles

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