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dc.contributor.authorSewram Ven
dc.contributor.authorSitas Fen
dc.contributor.authorO'Connell DLen
dc.contributor.authorMyers Jen
dc.description.abstractA multicenter hospital-based case-control study comprising 670 incident cases of esophageal cancer (EC) and 1188 controls, frequency-matched for age and sex, was conducted to evaluate the role of diet on EC development in the Eastern Cape Province, South Africa. A locally relevant lifestyle and dietary questionnaire was used. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional multivariable logistic regression. Individually, maize or sorghum consumption vs. never or rare consumption were not associated with EC (P > 0.1). Males and females consuming green leafy vegetables 5-7 days/wk had 38% (P = 0.04) and 50% (P = 0.007) reduced odds of developing EC, respectively, compared with consumption </=1 day/wk. A similar reduction in odds was observed with fruit consumption. Principal component factor analysis revealed 3 distinct dietary patterns. In females, high vs. low consumption of Pattern 1 (sorghum, green leafy vegetables, green legumes, fruits, meat) was inversely associated with EC development (OR = 0.54; 95% CI: 0.34-0.89), whereas for Pattern 2 (maize, wild greens-imifino, dry beans) the odds were elevated (OR = 1.67; 95% CI: 1.04-2.67). Compared with low adherence, high adherence to Pattern 3 (wheat-based products) reduced the odds by 35% for both sexes. This study provides further evidence on the role of diet in minimizing EC risk in this populationen
dc.subject.otherCancer Type - Oesophageal Canceren
dc.subject.otherEtiology - Exogenous Factors in the Origin and Cause of Canceren
dc.titleDiet and esophageal cancer risk in the eastern cape province of South Africaen
dc.typePeer Reviewed Journal Articleen
dc.subject.keywordsSouth Africaen
dc.subject.keywordsConfidence Intervalsen
dc.subject.keywordsOdds Ratioen
dc.identifier.journaltitleNutrition and Canceren
dc.identifier.programmeCancer Causesen
dc.identifier.divisionCancer Research Division-
Appears in Collections:Research Articles

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