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|Title:||Diet and esophageal cancer risk in the eastern cape province of South Africa|
|Authors:||Sewram V; Sitas F; O'Connell DL; Myers J|
|Categories:||Cancer Type - Oesophageal Cancer|
Etiology - Exogenous Factors in the Origin and Cause of Cancer
|Keywords:||Africa; South Africa; analysis; cancer; Confidence Intervals; Female; Male; Odds Ratio; Research; Risk|
|Journal Title:||Nutrition and Cancer|
|Page number start:||791|
|Page number end:||799|
|Abstract:||A multicenter hospital-based case-control study comprising 670 incident cases of esophageal cancer (EC) and 1188 controls, frequency-matched for age and sex, was conducted to evaluate the role of diet on EC development in the Eastern Cape Province, South Africa. A locally relevant lifestyle and dietary questionnaire was used. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional multivariable logistic regression. Individually, maize or sorghum consumption vs. never or rare consumption were not associated with EC (P > 0.1). Males and females consuming green leafy vegetables 5-7 days/wk had 38% (P = 0.04) and 50% (P = 0.007) reduced odds of developing EC, respectively, compared with consumption </=1 day/wk. A similar reduction in odds was observed with fruit consumption. Principal component factor analysis revealed 3 distinct dietary patterns. In females, high vs. low consumption of Pattern 1 (sorghum, green leafy vegetables, green legumes, fruits, meat) was inversely associated with EC development (OR = 0.54; 95% CI: 0.34-0.89), whereas for Pattern 2 (maize, wild greens-imifino, dry beans) the odds were elevated (OR = 1.67; 95% CI: 1.04-2.67). Compared with low adherence, high adherence to Pattern 3 (wheat-based products) reduced the odds by 35% for both sexes. This study provides further evidence on the role of diet in minimizing EC risk in this population|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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