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Title: Characteristics of cases with unknown stage prostate cancer in a population-based cancer registry
Authors: Luo Q; Yu XQ; Cooke-Yarborough C; Smith DP; O'Connell DL
Categories: Cancer Type - Prostate Cancer
Cancer Control, Survivorship, and Outcomes Research - Resources and Infrastructure
Keywords: Australia; prostate; Public Health; regional; Registries; Research; survival; Wales; cancer; cancer registry; diagnosis; Health Services; methods; New South Wales; Other; Proportional Hazards Models
Year: 2014
Journal Title: Cancer Epidemiology
Volume: 37
Issue: 6
Page number start: 813
Page number end: 819
Abstract: BACKGROUND: The New South Wales Central Cancer Registry (NSW CCR) is the only population-based cancer registry in Australia that has routinely collected summary stage at diagnosis since its inception in 1972. However, a large proportion of prostate cancer cases have 'unknown' stage recorded by the registry. We investigated the characteristics of prostate cancer cases with 'unknown' stage recorded by the NSW CCR, and examined survival for this group. METHODS: Data were obtained from the NSW CCR for all first primary prostate cancer cases diagnosed in 1999-2007. Summary stage was recorded as localised, regional, distant or 'unknown'. Associations between disease stage and patient characteristics (age, place of residence at diagnosis, year of diagnosis and country of birth) and prostate cancer specific survival were investigated using multivariable logistic regression and Cox proportional hazards models respectively. RESULTS: Of 39852 prostate cancer cases, 41.8% had 'unknown' stage recorded by the NSW CCR. This proportion decreased significantly over time, increased with increasing age at diagnosis and was higher for those living in socio-economically disadvantaged areas. The proportion with 'unknown' stage varied across area health services. Prostate cancer specific survival for cases with 'unknown' stage was significantly poorer than for those with localised stage but better than for those with regional or distant stage. CONCLUSIONS: Researchers or others using cancer registry stage data to examine prostate cancer outcomes need to consider the differences between cases with 'unknown' stage at diagnosis and those with known stage recorded by the registry, and what impact this may have on their results
Programme: Health Services
Division: Cancer Research Division
Funding Body: This study was funded by the Prostate Cancer Foundation of Australia (YI-0410). Xue Qin Yu and David Smith are supported by Australian National Health and Medical Research Council Training Fellowships (App550002 and App1016598 respectively)
DOI: 10.1016/j.canep.2013.09.008
Appears in Collections:Research Articles

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