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Title: A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study
Authors: Cairns BJ; Travis RC; Wang XS; Reeves GK; Green J; Beral V; for the Million Women Study Collaborators (incl. Canfell K)
Categories: Etiology - Exogenous Factors in the Origin and Cause of Cancer
Cancer Type - Breast Cancer
Keywords: breast; methods; Middle Aged; Neoplasms; Other; Prospective Studies; Research; Risk; Risk Factors; Sleep Disorders; Women; Breast Neoplasms; cancer; Cohort Studies; epidemiology; Female; Follow-Up Studies; Great Britain; Humans
Year: 2012
Journal Title: British Journal of Cancer
Volume: 107
Issue: 3
Page number start: 527
Page number end: 530
Abstract: BACKGROUND: Sleep disturbance, a correlate of which is daytime napping, has been hypothesised to be associated with risk of breast and other cancers. METHODS: We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of middle-aged women in the UK. RESULTS: During an average of 7.4 years of follow-up, 20 058 breast cancers and 31 856 other cancers were diagnosed. Over the first 4 years of follow-up, daytime napping (sometimes/usually vs rarely/never) was associated with slightly increased risks of breast cancer (RR=1.10, 95% CI 1.06-1.15) and of other cancers (RR=1.12, 1.08-1.15), but the RRs decreased significantly with increasing follow-up time (P=0.001 and P=0.01, respectively, for trend). Four or more years after baseline, there was no elevated risk of breast cancer (RR=1.00, 0.96-1.05), and only marginally greater risk of other cancers (RR=1.04, 1.01-1.07). CONCLUSION: The effect of pre-clinical disease is a likely explanation for the short-term increased risk of breast and other cancers associated with daytime napping
Programme: Epi Mod Screen
Division: Cancer Research Division
Funding Body: The Million Women Study is supported by the Cancer Research UK, the UK Medical Research Council, the UK National Health Service breast cancer screening programme, and the UK Health and Safety Executive. KC was supported by a NHMRC Fellowship (GNT1007994)
DOI: 10.1038/bjc.2012.291
URI: http://researchpubs.cancercouncil.com.au/cancercounciljspui/handle/1/1575
Appears in Collections:Research Articles

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