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Title: A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study
Authors: Cairns BJ
Travis RC
Wang XS
Reeves GK
Green J
Beral V
Categories: Population Groups - International
Projects & Studies - The Million Women Study
Keywords: breast; methods; Middle Aged; Neoplasms; Other; Prospective Studies; Research; Risk; Risk Factors; Sleep Disorders; Women; Breast Neoplasms; cancer; Cohort Studies; epidemiology; Female; Follow-Up Studies; Great Britain; Humans
Pub. Date: 2012
Journal Title: Br J Cancer
Volume: 107
Issue: 3
Page number start: 527
Page number end: 530
Abstract: BACKGROUND: Sleep disturbance, a correlate of which is daytime napping, has been hypothesised to be associated with risk of breast and other cancers. METHODS: We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of middle-aged women in the UK. RESULTS: During an average of 7.4 years of follow-up, 20 058 breast cancers and 31 856 other cancers were diagnosed. Over the first 4 years of follow-up, daytime napping (sometimes/usually vs rarely/never) was associated with slightly increased risks of breast cancer (RR=1.10, 95% CI 1.06-1.15) and of other cancers (RR=1.12, 1.08-1.15), but the RRs decreased significantly with increasing follow-up time (P=0.001 and P=0.01, respectively, for trend). Four or more years after baseline, there was no elevated risk of breast cancer (RR=1.00, 0.96-1.05), and only marginally greater risk of other cancers (RR=1.04, 1.01-1.07). CONCLUSION: The effect of pre-clinical disease is a likely explanation for the short-term increased risk of breast and other cancers associated with daytime napping
Programme: Epi Mod Screen
Division: Cancer Research Division
DOI: 10.1038/bjc.2012.291
Appears in Collections:Research Articles

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