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|Title:||A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study|
|Categories:||Population Groups - International|
Projects & Studies - The Million Women Study
|Keywords:||breast; methods; Middle Aged; Neoplasms; Other; Prospective Studies; Research; Risk; Risk Factors; Sleep Disorders; Women; Breast Neoplasms; cancer; Cohort Studies; epidemiology; Female; Follow-Up Studies; Great Britain; Humans|
|Journal Title:||Br J Cancer|
|Page number start:||527|
|Page number end:||530|
|Abstract:||BACKGROUND: Sleep disturbance, a correlate of which is daytime napping, has been hypothesised to be associated with risk of breast and other cancers. METHODS: We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of middle-aged women in the UK. RESULTS: During an average of 7.4 years of follow-up, 20 058 breast cancers and 31 856 other cancers were diagnosed. Over the first 4 years of follow-up, daytime napping (sometimes/usually vs rarely/never) was associated with slightly increased risks of breast cancer (RR=1.10, 95% CI 1.06-1.15) and of other cancers (RR=1.12, 1.08-1.15), but the RRs decreased significantly with increasing follow-up time (P=0.001 and P=0.01, respectively, for trend). Four or more years after baseline, there was no elevated risk of breast cancer (RR=1.00, 0.96-1.05), and only marginally greater risk of other cancers (RR=1.04, 1.01-1.07). CONCLUSION: The effect of pre-clinical disease is a likely explanation for the short-term increased risk of breast and other cancers associated with daytime napping|
|Programme:||Epi Mod Screen|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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