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|Title:||The importance of blood-borne viruses in elevated cancer risk among opioid-dependent people: a population-based cohort study|
|Authors:||Swart A; Vajdic CM; Burns L; Mao L; Grulich AE; Amin J; O'Connell DL; Meagher NS; Randall D; Degenhardt L|
|Categories:||Cancer Type - All Cancers combined|
Etiology - Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors
|Keywords:||Adult; Incidence; Lung; Lymphoma; New South Wales; prostate; Registries; Research; Risk; therapy; Wales; Aged; Australia; breast; cancer; Cohort Studies; Design; Hepatitis B; Hepatitis C|
|Journal Title:||BMJ Open|
|Abstract:||OBJECTIVE: To quantify cancer risk in opioid dependence and the association with infection by the oncogenic blood-borne viruses (BBVs) hepatitis C (HCV), hepatitis B (HBV) and HIV. DESIGN: Cohort study. SETTING: New South Wales, Australia. PARTICIPANTS: All 45 412 adults aged 16 years or over registered for opioid substitution therapy (OST) between 1985 and 2007. Notifications of cancer, death and infection with HCV, HBV and HIV were ascertained by record linkage with registries. MAIN OUTCOME MEASURES: The ratios of observed to expected number of cancers, standardised incidence ratios (SIRs), and the average annual per cent change (AAPC) in overall age and sex-standardised cancer incidence. RESULTS: Overall cancer risk was modestly increased compared to the general population (SIR 1.15, 95% CI 1.07 to 1.23). Excess risk was observed for 11 cancers, particularly lung (4.02, 95% CI 3.32 to 4.82), non-Hodgkin's lymphoma (1.51, 95% CI 1.20 to 1.88) and liver (8.04, 95% CI 6.18 to 10.3). Reduced risk was observed for six cancers, including prostate (0.16, 95% CI 0.06 to 0.32) and breast (0.48, 95% CI 0.35 to 0.62). Individuals notified with HCV or HBV had a markedly increased risk of liver cancer; lung cancer risk was also increased in those with HCV. HIV was associated with an elevated risk of liver, anus and kidney cancer, non-Hodgkin lymphoma and Kaposi sarcoma. Cancer risk was not increased in individuals without a BBV notification, apart from pancreatic cancer (3.92, 95% CI 1.07 to 10.0). Cancer incidence increased significantly over time (AAPC 9.4%, 4.2% to 15%, p=0.001). CONCLUSIONS: BBVs play a major role in the cancer risk profile of opioid-dependent individuals registered for OST. To address the dramatic increasing trend in cancer incidence, the OST setting could be utilised for cancer prevention strategies|
|Division:||Cancer Research Division|
|Funding Body:||National Health and Medical Research Council (NHMRC; ID630531) and Faculty of Medicine, University of New South Wales. AEG is supported by an NHMRC principal research fellowship (ID568819). LD is supported by an NHMRC Senior Research Fellowship (ID510279). CMV is supported by an NHMRC Career Development Fellowship (ID1023159) and a Cancer Institute New South Wales Career Development Fellowship (ID10/CDF/2-42).|
|Appears in Collections:||Research Articles|
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