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Title: Attributable causes of cancer in China
Authors: Wang JB; Li L; Wang D; Deng SS; Chen WQ; Wei WQ; Qiao YL; Boffetta P; Jiang Y; Liang H; Li P; Xiao HJ; Ji J; Xiang W; Shi JF; Fan YG
Categories: Cancer Type - All Cancers combined
Etiology - Exogenous Factors in the Origin and Cause of Cancer
Keywords: Alcohol Drinking; Other; Prevalence; Risk; Risk Factors; Smoking; Tobacco; Women; cancer; China; Developing Countries; epidemiology; Incidence; methods; mortality; Occupational Exposure
Year: 2012
Journal Title: Annals of Oncology
Volume: 23
Issue: 11
Page number start: 2983
Page number end: 2989
Abstract: Background Most cancers are due to modifiable lifestyle and environmental risk factors, and are potentially preventable. No studies have provided a systematic quantitative assessment of the burden of cancer mortality and incidence attributable to known risk factors in China. Methods We calculated the proportions of cancer deaths and new cases attributable to known risk factors in China, based on the prevalence of exposure around 1990 and national data on cancer mortality and incidence for the year 2005. Results Chronic infection is the main risk factor for cancer in China, accounting for 29.4% of cancer deaths (31.7% in men and 25.3% in women), followed by tobacco smoking (22.6% with 32.7% in men and 5.0% in women), low fruit intake (13.0%), alcohol drinking (4.4%), low vegetable intake (3.6%) and occupational exposures (2.7%). The remaining factors, including environmental agents, physical inactivity, the use of exogenous hormones and reproductive factors are each responsible for <1.0%. Conclusions Modifiable risk factors explain nearly 60% of cancer deaths in China, with a predominant role of chronic infection and tobacco smoking. Our findings could provide a basis for cancer prevention and control programs aimed at reducing cancer risk in other developing countries
Programme: Cancer Causes
Division: Cancer Research Division
Funding Body: International Agency for Research on Cancer (Lyon, France; Grant number: CRA No GEE/08/19) and Cancer Institute, Chinese Academy of Medical Sciences (Beijing, China; Grant number: JK2011B19).
DOI: 10.1093/annonc/mds139
Appears in Collections:Research Articles

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