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|Title:||Time since first sexual intercourse and the risk of cervical cancer|
|Authors:||Plummer M; Peto J; Franceschi S; the International Collaboration of Epidemiological Studies of Cervical Cancer (incl. Sitas F and Canfell K)|
|Categories:||Cancer Type - Cervical Cancer|
Etiology - Exogenous Factors in the Origin and Cause of Cancer
|Keywords:||Adult; Confidence Intervals; etiology; Female; HPV; immunology; Incidence; Logistic Models; Menarche; Middle Aged; Age Factors; Odds Ratio; Papillomavirus Infections; Papillomavirus Vaccines; prevention & control; Research; Risk; Sexual Behavior; Time Factors; Uterine Cervical Neoplasms; Aged; Vaccination; Women; Bias (Epidemiology); breast; cancer; cervical; Cervical Cancer; complications|
|Journal Title:||International Journal of Cancer|
|Page number start:||2638|
|Page number end:||2644|
|Abstract:||Young age at first sexual intercourse (AFI) is an important risk factor for cervical cancer, but no simple statistical model of its influence has been established. We investigated the relationship between risk of cervical carcinoma and time since first intercourse using data on monogamous women (5,074 cases and 16,137 controls) from the International Collaboration of Epidemiological Studies of Cervical Cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from pooled data on 20 studies using conditional logistic regression. The OR for invasive cervical carcinoma is approximately proportional to the square of time since first intercourse (exponent 1.95, 95% CI: 1.76-2.15) up to age 45. First cervical infection with human papillomavirus (HPV) often occurs soon after first sexual intercourse, so early AFI is a reasonable proxy for early age at first exposure to HPV. In addition, age-specific incidence rates of cervical cancer in unscreened populations remain fairly constant above age 45. Cervical cancer thus resembles other cancers caused by strong early-stage carcinogens, with incidence rates proportional to a power of time since first exposure and also resembles cancers of the breast and other hormone-dependent epithelia, where a similar flattening of age-specific incidence rates is seen at the time menopausal changes start. Taken together, these observations suggest that HPV vaccination may prevent the majority of cervical cancers by delaying HPV infection without necessarily providing lifetime protection against HPV|
|Division:||Cancer Research Division|
|Funding Body:||UNPD/UNFPA/WHO/World Bank Special Program of Research, Development, and Research Training in HumanReproduction, Department of Reproductive Health and Research, World Health Organization; International Agency for Research on Cancer(IARC); Cancer Research UK|
|Appears in Collections:||Research Articles|
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