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Title: Time since first sexual intercourse and the risk of cervical cancer
Authors: Plummer M
Peto J
Franceschi S
International COllaboration of Epidemiological Studies of Cervical Cancer (incl Canfell K and Sitas F)
Categories: Cancer Type - Cervical Cancer
Causes & Exposures - HPV
Population Groups - Women's Health
Statistical & Methodological Research - Mathematical Modelling
Keywords: Adult; Confidence Intervals; etiology; Female; HPV; Humans; immunology; Incidence; Logistic Models; Menarche; Middle Aged; Age Factors; Odds Ratio; Other; Papillomavirus Infections; Papillomavirus Vaccines; prevention & control; Research; Risk; Sexual Behavior; Time Factors; Uterine Cervical Neoplasms; Aged; Vaccination; Women; Bias (Epidemiology); breast; cancer; cervical; Cervical Cancer; complications
Pub. Date: 2012
Journal Title: Int J Cancer
Volume: 130
Issue: 11
Page number start: 2638
Page number end: 2644
Abstract: Young age at first sexual intercourse (AFI) is an important risk factor for cervical cancer, but no simple statistical model of its influence has been established. We investigated the relationship between risk of cervical carcinoma and time since first intercourse using data on monogamous women (5,074 cases and 16,137 controls) from the International Collaboration of Epidemiological Studies of Cervical Cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from pooled data on 20 studies using conditional logistic regression. The OR for invasive cervical carcinoma is approximately proportional to the square of time since first intercourse (exponent 1.95, 95% CI: 1.76-2.15) up to age 45. First cervical infection with human papillomavirus (HPV) often occurs soon after first sexual intercourse, so early AFI is a reasonable proxy for early age at first exposure to HPV. In addition, age-specific incidence rates of cervical cancer in unscreened populations remain fairly constant above age 45. Cervical cancer thus resembles other cancers caused by strong early-stage carcinogens, with incidence rates proportional to a power of time since first exposure and also resembles cancers of the breast and other hormone-dependent epithelia, where a similar flattening of age-specific incidence rates is seen at the time menopausal changes start. Taken together, these observations suggest that HPV vaccination may prevent the majority of cervical cancers by delaying HPV infection without necessarily providing lifetime protection against HPV
Programme: Cancer Causes
Division: Cancer Research Division
DOI: 10.1002/ijc.26250
Appears in Collections:Research Articles

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