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Title: Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort
Authors: Green J; Roddam A; Pirie K; Kirichek O; Reeves G; Beral V; for the Million Women Study Collaborators (incl. Canfell K)
Categories: Cancer Type - Gastric Cancer
Cancer Type - Oesophageal Cancer
Etiology - Endogenous Factors in the Origin and Cause of Cancer
Keywords: Aged; Menopause; methods; Middle Aged; physiopathology; Proportional Hazards Models; Reproduction; Research; Risk; Risk Factors; Stomach Neoplasms; cancer; Women; Cohort Studies; Confidence Intervals; epidemiology; Esophageal Neoplasms; Female; history; Humans
Year: 2012
Journal Title: British Journal of Cancer
Volume: 106
Issue: 1
Page number start: 210
Page number end: 216
Abstract: BACKGROUND: Hormonal factors may influence risk for upper gastrointestinal cancers in women. We examined risk of oesophageal and gastric cancers in relation to reproductive factors in a large UK cohort, the Million Women Study. METHODS: Among 1,319,409 women aged on average 56 years at recruitment, 1186 incident cancers of the oesophagus and 1194 of the stomach were registered during 11.9 million person-years' observation. Adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. RESULTS: Risks of both oesophageal and gastric cancer were significantly higher in postmenopausal than in pre- or peri-menopausal women (RRs 1.46, 1.07-2.00 and 1.59, 1.15-2.20, respectively; P</=0.01 for both); and, among postmenopausal women, risk was higher the younger women were at menopause (RR, 95% CI per 5 years younger at menopause 1.18, 1.05-1.34 for oesophageal cancer and 1.18, 1.04-1.34 for stomach cancer, P(trend)=0.01 for both). For factors relating to childbearing, including women's age at first birth, their number of children, and breastfeeding history, the only significant association was a higher risk of oesophageal cancer in nulliparous, compared with parous, women (RR 1.31, 1.11-1.55; P=0.002). When risks for squamous cell and adenocarcinomas of the oesophagus were compared, most did not differ significantly, but statistical power was limited. CONCLUSION: Both oesophageal and gastric cancer risks appeared to be related to menopausal status and age at menopause, but there was little consistent evidence for associations with factors related to childbearing
Programme: Cancer Causes
Division: Cancer Research Division
Funding Body: The Million Women Study is funded by the Cancer Research UK and the UK Medical Research Council. KC received salary support from the National Health and Medical Research Council of Australia (CDF #1082989).
DOI: 10.1038/bjc.2011.525
Appears in Collections:Research Articles

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