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Title: Sun exposure may increase risk of prostate cancer in the high UV environment of New South Wales, Australia: A case-control study
Authors: Nair-Shalliker V; Smith DP; Egger S; Hughes AM; Kaldor JM; Clements M; Kricker A; Armstrong BK
Categories: Cancer Type - Prostate Cancer
Etiology - Exogenous Factors in the Origin and Cause of Cancer
Keywords: Australia; Risk; sun exposure; Sunlight; Wales; cancer; Case-Control Studies; epidemiology; Lymphoma; New South Wales; prostate; Public Health; Research
Year: 2012
Journal Title: International Journal of Cancer
Volume: 131
Issue: 5
Page number start: E726
Page number end: E732
Abstract: Ultraviolet (UV) radiation in sunlight may influence risk of prostate cancer. In New South Wales (NSW), Australia, we examined the relationship between sun exposure at 30 and 50 years of age and risk of prostate cancer in a case-control study combining the NSW prostate cancer care and outcome study (cases) and the NSW non-Hodgkin's lymphoma study (controls). Prostate cancer risk increased with increasing estimated sun exposure (adjusted OR for highest vs. lowest quartiles of average weekly sun exposure in the warmer months 2.07 95% CI: 1.36-3.15) and this increase was most evident with weekend sun exposure (adjusted OR = 5.55, 95% CI: 2.94-10.48). High sun sensitivity was also positively associated with risk for prostate cancer (adjusted OR = 1.63, 95% CI: 1.09-2.44). The apparent effects of weekly sun exposure did not vary by disease aggressiveness. Our results suggest that increasing sun exposure in mid-adult years increases prostate cancer risk in a high ambient solar UV environment. Given that previous studies, conducted mainly in low solar UV environments, have generally found evidence of a negative association, our findings suggest there may be a U-shaped relationship between solar UV exposure and prostate cancer. Further studies are needed to test the hypothesis that high solar UV exposure is a risk factor for prostate cancer and to explore possible mechanisms for such an association
Programme: Cancer Causes
Division: Cancer Research Division
Funding Body: (1) National Health and Medical Research Council (NHMRC). Grant Number: 990920 (NHL Study) and 464850 (PCOSun study) (2) Australian Commonwealth Department of Veterans Affairs. Grant Number: 387700 (PCOS) (3) DPS was supported by a National Health and Medical Research Council Training Fellowship (APP1016598)
DOI: 10.1002/ijc.27400
Appears in Collections:Research Articles

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