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Title: The burden of cervical cancer in China: Synthesis of the evidence
Authors: Shi JF; Canfell K; Lew JB; Qiao YL
Categories: Cancer Type - Cervical Cancer
Cancer Control, Survivorship, and Outcomes Research - Resources and Infrastructure
Keywords: Aged; mortality; New South Wales; Other; Prevalence; Public Health; Registries; Research; Wales; Women; Australia; cancer; cervical; Cervical Cancer; China; epidemiology; Incidence; Meta-Analysis
Year: 2012
Journal Title: International Journal of Cancer
Volume: 130
Issue: 3
Page number start: 641
Page number end: 652
Abstract: The burden of cervical cancer in China has not been characterized in detail. We reviewed cervical cancer data from national mortality surveys and registries, and conducted a meta-analysis to estimate the prevalence of high-grade lesions (HSIL) and high-risk human papillomavirus (HR-HPV) infections in rural Shanxi Province. We found that a national survey in the 1970s estimated age-standardized cervical cancer mortality rates as approximately 15 and approximately 83/100,000 women nationally and in Xiangyuan, Shanxi; but the latest survey (2004-2005) found much lower rates of approximately 3 and approximately 7/100,000, respectively. IARC registries record age-standardized cervical cancer incidence in China as <5/100,000 (1998-2002); but the five registry sites cover <2% of the population, and the gross domestic product per capita at each of the registry sites is higher than China's average (by a factor ranging from 1.3 to 3.9). The pooled estimate of the prevalence of HSIL and HR-HPV in women aged 30-54 years in Shanxi was 3.7%(95%CI:2.7-4.8%) and 17.2%(95%CI:13.1-21.3%), respectively. Based on a feasible range informed by the incidence data for China and other unscreened populations, the predicted indicative annual number of new cervical cancer cases nationally, in the absence of any intervention, ranges from approximately 27,000 to 130,000 (2010) to 42,000 to 187,000 (2050). In conclusion, recent data suggest comparatively low rates of cervical cancer incidence in China, which may be partly explained by the location of registry sites in higher socioeconomic status areas. However, the evidence is consistent with considerable heterogeneity within China, with a higher disease burden in some rural areas such as Shanxi. Therefore, the lower reported rates of cervical cancer in China should be interpreted cautiously
Programme: Epi Mod Screen
Division: Cancer Research Division
Funding Body: UICC American Cancer Society Beginning Investigators Fellowship; Grant number: ACS/09/008; Grant sponsor: CancerCouncil NSW, Australia. KC received salary support from the National Health and Medical Research Council of Australia (CDF #1082989).
DOI: 10.1002/ijc.26042
Appears in Collections:Research Articles

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