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Title: Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study
Authors: Benson VS; Green J; Pirie K; Beral V; for the Million Women Study Collaborators (incl. Canfell K)
Categories: Cancer Type - Acoustic neuroma
Cancer Type - Pituitary tumours
Etiology - Exogenous Factors in the Origin and Cause of Cancer
Keywords: cancer; Women; epidemiology; Incidence; methods; Middle Aged; Prospective Studies; Research; Risk; Smoking
Year: 2010
Journal Title: British Journal of Cancer
Volume: 102
Issue: 11
Page number start: 1654
Page number end: 1656
Abstract: BACKGROUND: The relationship between cigarette smoking and incidence of acoustic neuromas and pituitary tumours is uncertain. METHODS: We examined the relation between smoking and risk of acoustic neuromas and pituitary tumours in a prospective study of 1.2 million middle-aged women in the United Kingdom. RESULTS: Over 10.2 million person years of follow-up, 177 women were diagnosed with acoustic neuromas and 174 with pituitary tumours. Current smokers at recruitment were at significantly reduced risk of incident acoustic neuroma compared with never smokers (adjusted relative risk (RR)=0.41, 95% confidence interval (CI)=0.24-0.70, P=0.001). Past smokers did not have significantly different risk of acoustic neuroma than never smokers (RR=0.87, 95% CI=0.62-1.22, P=0.4). Smoking was not associated with incidence of pituitary tumours (RR in current vs never smokers=0.91, 95% CI=0.60-1.40, P=0.7). CONCLUSION: Women who smoke are at a significantly reduced risk of acoustic neuromas, but not of pituitary tumours, compared with never smokers. Acoustic neuromas are much rarer than the cancers that are increased among smokers
Programme: Cancer Causes; Million Women Study
Division: Cancer Research Division
Appears in Collections:Research Articles

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