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|Title:||Improved survival for non-Hodgkin lymphoma patients in New South Wales, Australia|
|Authors:||Yu XQ; Chen WH; O'Connell DL|
|Categories:||Cancer Type - Non-Hodgkins Lymphoma|
Cancer Control, Survivorship, and Outcomes Research - Surveillance
|Keywords:||Australia; survival; trends; Wales; Clinical Trials; diagnosis; Incidence; Lymphoma; methods; mortality; New South Wales; Risk|
|Journal Title:||BMC Cancer|
|Page number start:||231|
|Abstract:||ABSTRACT: BACKGROUND: We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. METHODS: NHL cases diagnosed in 1985-2004 in New South Wales (NSW) were followed-up to the end of 2004. Rituximab prescription data were obtained from Medicare Australia. Using a Poisson regression model adjusted for age group, sex, NHL subtype and time period (1990-1994, 1995-1999 and 2000-2004), we estimated excess risk of death after a diagnosis of NHL. To give context to the survival trend, trends in incidence and mortality were also estimated. RESULTS: Compared with 1990-1994, after adjusting for age, sex and NHL subtype the relative excess risk of death was significantly lower (p<0.0001) in 1995-1999 (0.89) and 2000-2004 (0.74). A sharp fall in mortality was observed from 2000 to 2004 (annual percentage change (APC) = -4.7, p=0.009), while a small but significant rise in incidence was seen from 1990 to 2004 (APC = 0.5, p=0.01). The number of times rituximab was dispensed in NSW increased rapidly from 1274 in 1999 to 9250 in 2004. CONCLUSION: It is likely that some benefit of adding rituximab to the standard chemotherapy for NHL has been experienced at the population level|
|Programme:||Health Services Research; NHL Survival|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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