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|Title:||Effects of tobacco smoking on cancer and cardiovascular disease in urban black South Africans|
|Authors:||Stein L; Urban MI; Weber MF; Ruff P; Hale M; Donde B; Patel M; Sitas F|
|Categories:||Etiology - Resources and Infrastructure|
|Keywords:||Adult; Cardiovascular Diseases; Case-Control Studies; Cervix; Confidence Intervals; epidemiology; etiology; Female; Humans; Incidence; Life Style; adverse effects; Lung; Male; Middle Aged; Neoplasms; Odds Ratio; Other; Prevalence; Research; Risk; Smoking; Africa; South Africa; statistics & numerical data; Tobacco; Urban Population; Women; African Continental Ancestry Group; Age Distribution; Age Factors; Aged; Aged,80 and over; cancer|
|Journal Title:||British Journal of Cancer|
|Page number start:||1586|
|Page number end:||1592|
|Abstract:||Demographic and lifestyle information from 9690 black patients diagnosed with cancer or cardiovascular disease was collected in an ongoing case-control study in Johannesburg, South Africa. Compared to never smokers, the odds ratio (OR) for lung cancer among current smokers was 16.3 (95% confidence interval (CI), 9.6-27.6) for men and 6.4 (95% CI, 4.0-10.4) for women. The corresponding OR for other smoking-related cancers was 4.6 (95% CI, 3.7-5.7) among men and 1.9 (95% CI, 1.6-2.2) among women, and for cardiovascular disease, 3.4 (95% CI, 2.1-5.4) among men and 1.5 (95% CI, 1.1-2.1) among women. Risks were higher among smokers than former smokers, and all risk estimates increased with increasing levels of smoking duration and intensity. Non-electric domestic fuel was associated with approximately 60% increase in the risk of smoking-related cancer, but not cardiovascular disease. Risks for cancers of cervix, oesophagus, oral cavity/pharynx, stomach, larynx, pancreas and anogenital region, as well as squamous cell carcinoma of skin were all significantly higher among current than never-smokers, with ORs ranging from 1.5 for cervix (95% CI, 1.2-1.8) to 14.7 for larynx (95% CI, 7.2-30). The risks of tobacco-related disease reported here are similar to that currently observed in Western countries, even though cigarette consumption is relatively low in this population|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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