Search publications
Title: Trends in prognostic factors and survival from cutaneous melanoma in Yorkshire, UK and New South Wales, Australia between 1993 and 2003
Authors: Downing A; Yu XQ; Newton-Bishop J; Forman D
Categories: Cancer Control, Survivorship, and Outcomes Research - Resources and Infrastructure
Keywords: Adolescent; detection; epidemiology; Female; Great Britain; Humans; Incidence; Male; Melanoma; Middle Aged; mortality; Adult; New South Wales; pathology; prevention & control; Prognosis; Registries; relative survival; Risk; Sex Factors; Skin Neoplasms; Socioeconomic Factors; Age Factors; survival; trends; Wales; Aged; Aged,80 and over; Australia; cancer; cancer registry; Carcinoma in Situ
Year: 2008
Journal Title: International Journal of Cancer
Volume: 123
Issue: 4
Page number start: 861
Page number end: 866
Abstract: The aim of this study was to compare trends in prognostic factors and survival from cutaneous melanoma between 1993 and 2003 in 2 populations with dramatically different underlying incidence rates [Yorkshire, UK, and New South Wales (NSW), Australia] and to look at whether the greater investment in melanoma prevention and early detection in Australia has resulted in any relative differences in survival. Patients diagnosed with invasive melanoma between 1993 and 2003 in Yorkshire (n = 4,170) and NSW (n = 30,520) were identified from cancer registry databases and prognostic information (age, sex, socioeconomic background, tumour site and Breslow thickness) was extracted. Age-standardised incidence rates, 5-year relative survival and relative excess risk of death were calculated. Between 1993-1995 and 2001-2003, the incidence of melanoma increased in both areas. These increases were mainly seen in tumours with thickness <or=1 mm. Five-year relative survival was 86.9% (95% CI 85.2-88.5) in Yorkshire and 88.6% (95% CI 88.1-89.1) in NSW. Compared with that in NSW, survival in Yorkshire was lower for males and for those living in the most deprived areas. Despite the increase in good prognosis of thin tumours, there was no significant change in survival over the time period in either area. After adjustment for differences in prognostic factors, the relative excess risk of death in Yorkshire compared to that in NSW reduced from 1.36 (95% CI 1.20-1.53) to 1.11 (95% CI 0.99-1.23). Differences in tumour thickness appeared to be the most important factor
Programme: Health Services Research
Division: Cancer Research Division
URI: http://researchpubs.cancercouncil.com.au/cancercounciljspui/handle/1/1440
Appears in Collections:Research Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.