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Title: Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women
Authors: Spurdle AB; Hopper JL; Chen X; McCredie MR; Giles GG; Newman B; Chenevix-Trench G
Categories: Etiology - Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors
Cancer Type - Breast Cancer
Keywords: Adult; Female; genetics; Genotype; history; Humans; Middle Aged; Odds Ratio; Polymorphism,Genetic; Proteins; Repressor Proteins; Aged; Research; Risk; Risk Factors; Women; Alleles; Australia; breast; Breast Neoplasms; cancer; Case-Control Studies; Family
Year: 2002
Journal Title: Breast Cancer Research
Volume: 360
Issue: 9337
Page number start: 925
Page number end: 926
Abstract: A C to T transition within the 3' untranslated region of the prohibitin gene alters mRNA function, and an association between the T allele and an increased risk of breast cancer has been reported in North American women, specifically in those aged under 50 years with a first-degree family history of breast cancer. We did a population-based case-control study to assess whether this association existed in Australian women. We did not note such an association in our sample of 1446 patients and 786 controls (odds ratio 0.96, 95% CI 0.80-1.16; p=0.7), or in subgroups defined by age or family history, or both. Hence, our results do not lend support to the hypothesis that this polymorphism contributes to risk of breast cancer
Programme: Cancer Causes
Division: Cancer Research Division
Appears in Collections:Research Articles

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