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|Title:||Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women|
|Authors:||Spurdle AB; Hopper JL; Chen X; McCredie MR; Giles GG; Newman B; Chenevix-Trench G|
|Categories:||Etiology - Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors|
Cancer Type - Breast Cancer
|Keywords:||Adult; Female; genetics; Genotype; history; Humans; Middle Aged; Odds Ratio; Polymorphism,Genetic; Proteins; Repressor Proteins; Aged; Research; Risk; Risk Factors; Women; Alleles; Australia; breast; Breast Neoplasms; cancer; Case-Control Studies; Family|
|Journal Title:||Breast Cancer Research|
|Page number start:||925|
|Page number end:||926|
|Abstract:||A C to T transition within the 3' untranslated region of the prohibitin gene alters mRNA function, and an association between the T allele and an increased risk of breast cancer has been reported in North American women, specifically in those aged under 50 years with a first-degree family history of breast cancer. We did a population-based case-control study to assess whether this association existed in Australian women. We did not note such an association in our sample of 1446 patients and 786 controls (odds ratio 0.96, 95% CI 0.80-1.16; p=0.7), or in subgroups defined by age or family history, or both. Hence, our results do not lend support to the hypothesis that this polymorphism contributes to risk of breast cancer|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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