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Title: A pooled analysis of 10 case-control studies of melanoma and oral contraceptive use
Authors: Karagas MR; Green A; Holly EA; Kirkpatrick CS; Mack T; Osterlind A; Rosso S; Swerdlow AJ; Stukel TA; Dykes J; Miglionico J; Greene MA; Carey M; Armstrong B; Elwood JM; Gallagher RP
Categories: Etiology - Resources and Infrastructure
Cancer Type - Skin Cancer
Keywords: Adolescent; epidemiology; etiology; Family; Female; history; Humans; Incidence; Melanoma; Middle Aged; Odds Ratio; Adult; Research Support,U.S.Gov't,P.H.S.; Risk; Risk Factors; Skin Neoplasms; sun exposure; Women; Women's Health; adverse effects; Aged; Aged,80 and over; analysis; Case-Control Studies; Contraceptives,Oral; Drug Administration Schedule
Year: 2002
Journal Title: Cancer Epidemiology, Biomarkers & Prevention
Volume: 86
Issue: 7
Page number start: 1085
Page number end: 1092
Abstract: Data regarding the effects of oral contraceptive use on women's risk of melanoma have been difficult to resolve. We undertook a pooled analysis of all case-control studies of melanoma in women completed as of July 1994 for which electronic data were available on oral contraceptive use along with other melanoma risk factors such as hair colour, sun sensitivity, family history of melanoma and sun exposure. Using the original data from each investigation (a total of 2391 cases and 3199 controls), we combined the study-specific odds ratios and standard errors to obtain a pooled estimate that incorporates inter-study heterogeneity. Overall, we observed no excess risk associated with oral contraceptive use for 1 year or longer compared to never use or use for less than 1 year (pooled odds ratio (pOR)=0.86; 95% CI=0.74-1.01), and there was no evidence of heterogeneity between studies. We found no relation between melanoma incidence and duration of oral contraceptive use, age began, year of use, years since first use or last use, or specifically current oral contraceptive use. In aggregate, our findings do not suggest a major role of oral contraceptive use on women's risk of melanoma
Programme: Bruce Armstrong
Division: Cancer Research Division
Appears in Collections:Research Articles

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