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Title: Specific infections, infection-related behavior, and risk of non-Hodgkin lymphoma in adults
Authors: Vajdic CM; Armstrong BK; Grulich AE; Kaldor JM; Fritschi L; Benke G; Hughes AM; Kricker A; Turner JJ; Milliken S
Keywords: Adult; New South Wales; Occupational Exposure; Odds Ratio; Other; Research; Risk; Risk Factors; Sexual Behavior; Telephone; Wales; Australia; Australian Capital Territory; blood; Case-Control Studies; epidemiology; Hepatitis C; history; Lymphoma
Year: 2006
Journal Title: Cancer Epidemiology, Biomarkers & Prevention
Volume: 15
Issue: 6
Page number start: 1102
Page number end: 1108
Abstract: Infections were examined as possible risk factors for non-Hodgkin lymphoma in a population-based case-control study in New South Wales and the Australian Capital Territory, Australia. Incident cases (n = 694) had no history of HIV infection or transplantation. Controls (n = 694) were randomly selected from electoral rolls and frequency matched to cases by age, sex, and area of residence. A postal questionnaire and telephone interview measured history of specific infections, occupational exposures, and behavioral and other risk factors for infection. Blood samples were tested for antibodies to human T-lymphotrophic virus type I and hepatitis C virus. Logistic regression models included the three matching variables and ethnicity. There was no association between risk of non-Hodgkin lymphoma and any of the variables analyzed, including sexually transmitted infections, sexual behavior, blood transfusions, influenza, acne, and either occupational or domestic exposure to zoonotic infections. Non-Hodgkin lymphoma risk was nonsignificantly elevated (odds ratio, 2.99; 95% confidence interval, 0.78-11.51) for those with a history of injecting drug use. Three cases and two controls (odds ratio, 1.32; 95% confidence interval, 0.22-7.98) tested positive to hepatitis C virus infection and none tested positive to human T-lymphotrophic virus type I/II infection. This study provides consistent evidence that sexually transmitted infections and zoonoses are not risk factors for non-Hodgkin lymphoma
Programme: Cancer Causes; NHL
Division: Cancer Research Division
URI: http://researchpubs.cancercouncil.com.au/cancercounciljspui/handle/1/1347
Appears in Collections:Research Articles

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