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|Title:||Cancer incidence in people with hepatitis B or C infection: A large community-based linkage study|
|Authors:||Amin J; Dore GJ; O'Connell DL; Bartlett M; Tracey E; Kaldor JM; Law MG|
|Keywords:||Australia; Research; Risk; cancer; cancer registry; epidemiology; Hepatitis B; Incidence; Lymphoma; methods; Registries|
|Journal Title:||Journal of Hepatology|
|Page number start:||197|
|Page number end:||203|
|Abstract:||BACKGROUND/AIMS: Risks of hepatocellular carcinoma (HCC) following hepatitis B and/or hepatitis C virus (HBV/HCV) infection are well known, those for other cancers are less well understood. The aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV infections. METHODS: The data from a cohort of 39109 HBV, 75834 HCV, and 2604 HBV/HCV co-infected persons notified to the State health department, 1990-2002, were probabilistically linked to the Cancer Registry and standardised incidence ratios (SIRs) for cancer were calculated. RESULTS: The match rate for any cancer was 2.7%, 2.3% and 3.3% for HBV, HCV and HBV/HCV co-infected notifications. SIRs for HCC were 30.6 (95% CI 25.7-36.5), 22.7 (95% CI 19.1-26.5) and 30.3 (95% CI 13.6-67.5), respectively. Increased risk was detected for Burkitt's lymphoma and HBV (SIR 12.9, 95% CI 5.4-30.9) and immunoproliferative malignancies following HCV (SIR 5.6, 95% CI 1.8-17.5). CONCLUSIONS: The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated cancers. The modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings|
|Programme:||Cancer Causes; Hep B|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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