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|Title:||Human herpesvirus-8 antibodies and DNA in HIV-1 infected patients in South Africa|
|Authors:||Alagiozoglou L; Morris L; Bredell H; Martin DJ; Sitas F|
|Categories:||Etiology - Resources and Infrastructure|
Cancer Type - Kaposi's Sarcoma
|Keywords:||Adult; genetics; Herpesvirus 8,Human; HIV Infections; Hiv-1; Humans; Immunoglobulin G; immunology; Male; Odds Ratio; pathogenicity; Africa; Research; Research Support,Non-U.S.Gov't; Risk; Sarcoma,Kaposi; South Africa; Viremia; virology; analysis; Antibodies,Viral; Antibody Formation; complications; Dna,Viral; Female; Fluorescent Antibody Technique|
|Journal Title:||Epidemiology and Infection|
|Page number start:||1125|
|Page number end:||1129|
|Abstract:||HIV-infected individuals with high levels of IgG antibodies against human herpesvirus-8 (HHV-8) are at increased risk of developing Kaposi's sarcoma. The aim of this study was to measure the association between HHV-8 viraemia and IgG antibody responses (by immunofluorescence) in a group of 201 HIV-infected individuals attending outpatient clinics, 91 in-patients with AIDS and 87 HIV-infected patients admitted with Kaposi's sarcoma. Compared to HIV-infected outpatients, the adjusted odds ratio in relation to Kaposi's sarcoma was 15.4 (95% CI 4.4-54.2) in those with viraemia, 25.1 (95% CI 6.6-95.6) in those with a positive immunofluorescent signal and infinity (lower exact CI 33.6) in those with a high immunofluorescent signal (all P trend < 0.001). Among those without HHV-8 viraemia, 23% were IgG-positive, but only 5.5% had a high immunofluorescent signal. In those who were viraemic, 89.1% were IgG-positive, and 28.2% had a high immunofluorescent signal, suggesting viraemia is associated with high HHV-8 immunofluorescence IgG signal|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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