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|Title:||Risk factors for high anti-HHV-8 antibody titers (> or =1:51,200) in black, HIV-1 negative South African cancer patients: a case control study|
|Authors:||Wojcicki JM; Sitas F; Newton R; Urban MI; Stein L; Hale M; Patel M; Ruff P; Sur R; Bourboulia D|
|Categories:||Etiology - Endogenous Factors in the Origin and Cause of Cancer|
Cancer Type - Kaposi's Sarcoma
|Keywords:||Adult; Case-Control Studies; Charcoal; epidemiology; Female; Gender; Herpesvirus 8,Human; HIV Seronegativity; Hiv-1; Humans; immunology; Africa; Male; methods; Middle Aged; Multivariate Analysis; Other; Poverty; Prevalence; Prospective Studies; Risk; Risk Factors; Age Distribution; Sarcoma,Kaposi; South Africa; United States; virology; Age Factors; Aged; analysis; Antibodies,Viral; blood; cancer|
|Journal Title:||BMC Infectious Diseases|
|Page number start:||21|
|Abstract:||BACKGROUND: Infection with human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the necessary causal agent in the development of Kaposi's sarcoma (KS). Infection with HIV-1, male gender and older age all increase risk for KS. However, the geographic distribution of HHV-8 and KS both prior to the HIV/AIDS epidemic and with HIV/AIDS suggest the presence of an additional co-factor in the development of KS. METHODS: Between January 1994 and October 1997, we interviewed 2576 black in-patients with cancer in Johannesburg and Soweto, South Africa. Blood was tested for antibodies against HIV-1 and HHV-8 and the study was restricted to 2191 HIV-1 negative patients. Antibodies against the latent nuclear antigen of HHV-8 encoded by orf73 were detected with an indirect immunofluorescence assay. We examined the relationship between high anti-HHV-8 antibody titers (> or =1:51,200) and sociodemographic and behavioral factors using unconditional logistic regression models. Variables that were significant at p = 0.10 were included in multivariate analysis. RESULTS: Of the 2191 HIV-1 negative patients who did not have Kaposi's sarcoma, 854 (39.0%) were positive for antibodies against HHV-8 according to the immunofluorescent assay. Among those seropositive for HHV-8, 530 (62.1%) had low titers (1:200), 227 (26.6%) had medium titers (1:51,200) and 97 (11.4%) had highest titers (1:204,800). Among the 2191 HIV-1 negative patients, the prevalence of high anti-HHV-8 antibody titers (> or =1:51,200) was independently associated with increasing age (p-trend = 0.04), having a marital status of separated or divorced (p = 0.003), using wood, coal or charcoal as fuel for cooking 20 years ago instead of electricity (p = 0.02) and consuming traditional maize beer more than one time a week (p = 0.02; p-trend for increasing consumption = 0.05) although this may be due to chance given the large number of predictors considered in this analysis. CONCLUSIONS: Among HIV-negative subjects, patients with high anti-HHV-8 antibody titers are characterized by older age. Other associations that may be factors in the development of high anti-HHV-8 titers include exposure to poverty or a low socioeconomic status environment and consumption of traditional maize beer. The relationship between these variables and high anti-HHV-8 titers requires further, prospective study|
|Division:||Cancer Research Division|
|Appears in Collections:||Research Articles|
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